Anti-aging gene injections could restore your heart age by 10 years

Elderly health heart health fitness - Kzenon/Alamy Stock Photo

Elderly health heart health fitness – Kzenon/Alamy Stock Photo

The scientists found that injecting the genes of the so-called “super-elders” into failing heart cells rejuvenated them and allowed them to function as if they were 10 years younger.

The discovery opens the door to treating or preventing heart failure by reprogramming damaged cells.

Researchers have long suspected that people living over 100 must have a unique genetic code that protects them from the ravages of old age.

Previous research has shown that carriers of a variant of the BP1FB4 gene have long lives and fewer heart problems.

In new experiments, scientists from the University of Bristol inserted the gene variant into a harmless virus and then injected it into aged mice. They found that it rewinds the heart’s biological clock by the human equivalent of 10 years.

When added to damaged aged human heart cells in the lab, the gene also triggered cardiac regeneration, triggering the building of new blood vessels and restoring lost function.

Hope to improve heart treatment

Paolo Madeddu, professor of experimental cardiovascular medicine at the Bristol Heart Institute at the University of Bristol, said: “Our findings confirm that the healthy mutant gene can reverse the decline in cardiac performance in older people.

“We are now interested in determining whether protein delivery instead of gene would also work. Gene therapy is widely used to treat diseases caused by bad genes. However, a protein-based therapy is safer and more viable than gene therapy.”

How well the heart can pump blood throughout the body deteriorates with age, but the rate at which harmful changes occur is not the same in all people.

Lifestyle choices can speed up or delay the biological clock, but inheriting protective genes is also crucial.

The study showed for the first time that such genes found in centenarians can be passed on to unrelated people to protect their hearts.

Monica Cattaneo, researcher from the MultiMedica Group in Milan and first author of the study, said: “By adding the longevity gene to the test tube, we observed a process of cardiac rejuvenation: the heart cells of older heart failure patients died. They continued to function properly and were more efficient at building new blood vessels. proved that.”

Professor James Leiper, deputy medical director of the British Heart Foundation, which funded the research, said of the results: “We all want to know the secrets of aging and how we can slow down age-related diseases.

“Our heart function declines with age, but this research has demonstrated spectacularly that a gene variant commonly found in people with longevity can stop and even reverse cardiac aging in mice.

“This is still early-stage research, but it could one day provide a revolutionary way to treat people with heart failure and even stop the debilitating condition from developing in the first place.”

The study was published in the journal Cardiovascular Research.

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